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Investigación

Realizamos investigación básica y aplicada en el área de la microbiología, con diversos proyectos nacionales e internacionales. Los tres grupos de investigación son:

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  • Biotecnología Molecular
  • Genética Molecular 
  • Bioinformática
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Ver publicaciones recientes

Proyectos

Diversidad microbiana y resistencia

  • Identificación y conservación de microorganismos ambientales

  • Comunidades microbianas asociadas a pianguas en el Pacífico

  • Microbiomas del sistema de bus Transmilenio en Bogotá

  • Resistencias en el ambiente

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Biomarcadores y diagnósticos

  • Diagnóstico molecular de M. tuberculosis

  • Transcriptómica en M. tuberculosis

  • Diagnósticos de enfermedades virales en Colombia

Metabolitos y enzimas microbianas

  • Identificación y estudio de genes biosintéticos en cepas de Streptomyces

  • Estudio de enzimas microbianas para favorecer cultivos de hongos comestibles

  • Desarrollo de un sistema molecular para aumentar expresión de genes en librerías metagenómicas. 

Bioinformática

  • Análisis del potencial metabólico en genomas y metagenomas 

  • Identificación de enzimas en metagenomas

Publcaciones

Publicaciones recientes

  • Iron deprivation enhances transcriptional responses to in vitro growth arrest of Mycobacterium tuberculosis. Alebouyeh S. et al. Front Microbiol. 2022 Oct 4;13:956602. doi: 10.3389/fmicb.2022.956602.

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  • The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment. García-Morales L et al. Front Cell Infect Microbiol. 2022 Jul 7;12:907890. doi: 10.3389/fcimb.2022.907890.

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  • Endotracheal tube microbiome in hospitalized patients defined largely by hospital environment. Cifuentes EA et al. Respir Res. 2022 Jun 24;23(1):168. doi: 10.1186/s12931-022-02086-7.

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  • Close Related Drug-Resistance Beijing Isolates of Mycobacterium tuberculosis Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model. Cerezo-Cortés MI et al. Int J Mol Sci. 2022 May 5;23(9):5157. doi: 10.3390/ijms23095157. PMID: 35563545

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  • Multilateral benefit-sharing from digital sequence information will support both science and biodiversity conservation. Scholz AH et al. Nat Commun. 2022 Feb 23;13(1):1086. doi: 10.1038/s41467-022-28594-0. PMID: 35197464

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  • Heterogeneous fitness landscape cues, pknG low expression, and phthiocerol dimycocerosate low production of Mycobacterium tuberculosis ATCC25618 rpoB S450L in enriched broth. Rodríguez-Beltrán É et al. Tuberculosis (Edinb). 2022 Jan;132:102156. doi: 10.1016/j.tube.2021.102156. Epub 2021 Dec 3. PMID: 34891037

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  • Genetic and Bioinformatic Strategies to Improve Diagnosis in Three Inherited Bleeding Disorders in Bogotá, Colombia. Lago et al. Genes (Basel). 2021 Nov 18;12(11):1807. doi: 10.3390/genes12111807.

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  • Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association. Wu et al. Environ Res. 2021 Oct 9;112183. doi: 10.1016/j.envres.2021.112183.

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  • A global metagenomic map of urban microbiomes and antimicrobial resistance. Danko et al. Cell. 2021 Jun 24;184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002. Epub 2021 May 26.

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  • Dissecting industrial fermentations of fine flavour cocoa through metagenomic analysis. Fernández-Niño et al.  Sci Rep. 2021 Apr 21;11(1):8638. doi: 10.1038/s41598-021-88048-3.

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  • COVID-19 drug practices risk antimicrobial resistance evolution. Afshinnekoo et al. Lancet Microbe. 2021 Apr;2(4):e135-e136. doi: 10.1016/S2666-5247(21)00039-2. Epub 2021 Feb 24.

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  • The effect of aminoglycosides on horizontal gene transfer in Klebsiella pneumoniae. Acosta IA et al. Rev. Acad. Colomb. Cienc. Ex. Fis. Nat. 2020. 44(170):105-120.Cell. 2021 Jun 24; 184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002. Epub 2021 May 26.

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  • The Microbiomes of Seven Lichen Genera Reveal Host Specificity, a Reduced Core Community and Potential as Source of Antimicrobials. Sierrra MA et al. Front. Microbiol. 2020. 11:398. doi: 10.3389/fmicb.2020.00398

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  • Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis. Pelaez et al. ACS Infect Dis. 2020 May 8;6(5):1110-1120. doi: 10.1021/acsinfecdis.9b00502. Epub 2020 Apr 14.

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  • Design and validation of a transposon that promotes expression of genes in episomal DNA. Mongui et al. J Biotechnol. 2020 Feb 20;310:1-5. doi: 10.1016/j.jbiotec.2020.01.007. Epub 2020 Jan 16.

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